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Figure 1 | Molecular Cancer

Figure 1

From: MicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1

Figure 1

Association between miR-181a expression in tumors and overall survival in CRC using qRT-PCR. (A) The levels of miR-181a in 137 CRC tissues (Validation Cohort 1) were significantly higher than those in matched adjacent normal tissues; (B) The levels of miR-181a were significantly higher in patients with synchronous (PSLM) and metachronous liver metastasis (PMLM) than those without liver metastasis (PNM); (C-E) The expression levels of miR-181a were positively correlated with advanced TNM stages, T stage and N stage. Expression of miR-181a was presented in log10 scale and was normalised against an endogenous reference U6; (F) Kaplan-Meier overall survival curves for CRC patients were compared according to miR-181a expression level. Patients with higher miR-181a expression displayed a shorter overall survival after surgery. (G-I) The expressions of miR-181b-d in 21 paired CRC patients with and without liver metastasis by qPCR.

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Molecular Cancer

ISSN: 1476-4598