Cohort 1 | Cohort 2 | |||||||
---|---|---|---|---|---|---|---|---|
Characteristic | Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||
HR (95% CI) | P Value | HR (95% CI) | PValue | HR (95% CI) | PValue | HR (95% CI) | P Value | |
miR-181a expression | 2.22 (1.307-3.77) | 0.003 | 1.871 (1.078-3.246) | 0.026 | 1.514 (1.223-1.874) | <0.001 | 1.382 (1.11-1.721) | 0.004 |
High | ||||||||
Low | ||||||||
Gender | 0.714 (0.423-1.206) | 0.208 | 1.119 (0.650-1.927) | 0.685 | 1.141 (0.845-1.54) | 0.39 | 1.001 (0.734-1.366) | 0.995 |
Male | ||||||||
Female | ||||||||
Age | 1.034 (0.621-1.723) | 0.898 | 1.023 (0.600-1.743) | 1.075 (0.795-1.453) | 0.637 | 1.147 (0.839-1.569) | 0.389 | |
≤60 (median) | 0.935 | |||||||
>60 | ||||||||
Venous invasion | 2.462 (1.476-4.108) | 0.001 | 1.243 (0.709-2.179) | 0.447 | 2.375 (1.758-3.21) | <0.001 | 1.593 (1.15-2.207) | 0.005 |
Positive | ||||||||
Negative | ||||||||
TNM stage | 11.057 (3.995-30.605) | <0.0001 | 30.732 (8.165-115.679) | <0.0001 | 6.509 (4.02-10.54) | <0.001 | 8.363 (4.414-15.846) | <0.001 |
I-П | ||||||||
III- IV | ||||||||
Histological type | 0.927 (0.290-2.966) | 0.899 | 0.550 (0.148-2.043) | 0.372 | 0.913 (0.428-1.945) | 0.813 | 0.806 (0.354-1.836) | 0.608 |
Adenocarcinoma | ||||||||
Mucinous adenocarcinoma | ||||||||
Lymph node metastasis | 4.27 (2.156-8.454) | <0.0001 | 3.578 (1.417-9.033) | 0.007 | 2.916 (2.062-4.125) | <0.001 | 1.686 (1.075-2.645) | 0.023 |
Positive | ||||||||
Negative | ||||||||
Differentiation | 0.629 (0.354-1.12) | 0.115 | 0.532 (0.277-1.024) | 0.059 | 0.438 (0.224-0.858) | 0.016 | 0.912 (0.433-1.919) | 0.808 |
Poor | ||||||||
well |