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Table 2 Univariate and multivariate Cox regression analysis of miR-181a expression levels and overall cancer survival in subjects with colorectal cancer

From: MicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1

 

Cohort 1

Cohort 2

Characteristic

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

 

HR (95% CI)

P Value

HR (95% CI)

PValue

HR (95% CI)

PValue

HR (95% CI)

P Value

miR-181a expression

2.22 (1.307-3.77)

0.003

1.871 (1.078-3.246)

0.026

1.514 (1.223-1.874)

<0.001

1.382 (1.11-1.721)

0.004

High

        

Low

        

Gender

0.714 (0.423-1.206)

0.208

1.119 (0.650-1.927)

0.685

1.141 (0.845-1.54)

0.39

1.001 (0.734-1.366)

0.995

Male

        

Female

        

Age

1.034 (0.621-1.723)

0.898

1.023 (0.600-1.743)

 

1.075 (0.795-1.453)

0.637

1.147 (0.839-1.569)

0.389

≤60 (median)

   

0.935

    

>60

        

Venous invasion

2.462 (1.476-4.108)

0.001

1.243 (0.709-2.179)

0.447

2.375 (1.758-3.21)

<0.001

1.593 (1.15-2.207)

0.005

Positive

        

Negative

        

TNM stage

11.057 (3.995-30.605)

<0.0001

30.732 (8.165-115.679)

<0.0001

6.509 (4.02-10.54)

<0.001

8.363 (4.414-15.846)

<0.001

I-П

        

III- IV

        

Histological type

0.927 (0.290-2.966)

0.899

0.550 (0.148-2.043)

0.372

0.913 (0.428-1.945)

0.813

0.806 (0.354-1.836)

0.608

Adenocarcinoma

        

Mucinous adenocarcinoma

        

Lymph node metastasis

4.27 (2.156-8.454)

<0.0001

3.578 (1.417-9.033)

0.007

2.916 (2.062-4.125)

<0.001

1.686 (1.075-2.645)

0.023

Positive

        

Negative

        

Differentiation

0.629 (0.354-1.12)

0.115

0.532 (0.277-1.024)

0.059

0.438 (0.224-0.858)

0.016

0.912 (0.433-1.919)

0.808

Poor

        

well