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Figure 3 | Molecular Cancer

Figure 3

From: TFAP2B overexpression contributes to tumor growth and a poor prognosis of human lung adenocarcinoma through modulation of ERK and VEGF/PEDF signaling

Figure 3

TFAP2B knockdown inhibits ERK/p38 MAPK signaling pathway. Human H1299 cells were transfected with the DC-based TFAP2B siRNA (si-TFAP2B) (A) or TFAP2B-expressing plasmids (B). At 48 hours after transfection, the levels of TFAP2B, total and phosphorylated ERK and p38 proteins were analyzed by Western blotting. H1299 cells were pre-treated with an ERK inhibitor U0126 (C) or a p38 inhibitor SB03580 (D) for 4 h, then transfected the cells with TFAP2B siRNA or expressing plasimd. After 48 h, cell viability was determined by MTT analysis. *P < 0.05, significant differences between the treatment groups and DMSO. U means U0126 and SB means SB03580.

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Molecular Cancer

ISSN: 1476-4598