Skip to main content
Figure 5 | Molecular Cancer

Figure 5

From: The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy

Figure 5

Regulation of polyploidy and cytokinesis by Aur A/B and BRCA1/2. A-B, Quantification of cells with multiple nuclei before or after the depletion of Aur A/B and BRCA1/2. Error bars = 95% CIs, indicating data were collected from three independently repeated experiments. C-D, Representative images showing the localization and accumulation of Aur A/B and BRCA1/2 at the midbody during cytokinesis (×1000). Blue dye DAPI indicates nucleus. Scale bars, 5 μm for the merged images and 1 μm for other images. E-F, Representative images of karyotypes before and after the silencing of Aur A/B or/and BRCA1/2 in Capan-1 cells (E) and OVCA433 cells (F).

Back to article page

Molecular Cancer

ISSN: 1476-4598