Figure 6From: SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1A schematic model of Grb2 SUMOylation-regulated ERK pathway. SUMOylation of Grb2 at K56 enhances the ERK activity via recruiting more Sos1 to form Grb2-Sos1 complex, and consequently promoting cell migration and tumorigenesis. Dashed line----Weak; Solid line----Strong.Back to article page