Figure 4
From: NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma
MiR-148a is overexpressed in gliomas. Real-time PCR analysis of miR-148a expression in (A) three normal brain tissues and 12 glioma tissues, and (B) NHAs and seven glioblastoma cell lines. Transcript levels were normalized to U6 expression. (C) MiR-148a upregulation was identified in 548 patients from the microarray data using published TCGA data. (D) Correlation between miR-148a levels and survival by Kaplan–Meier analysis of patients with low (<median, n = 269) or high (>median, n = 269) miR-148a expression. (E) GSEA plot showing that miR-148a expression correlated positively with glioma progression gene signatures in published TCGA patient gene expression profiles (n = 538). Each bar represents the mean ± SD of three independent experiments. *P < 0.05.