Table 1 Frequency of promoter hypermethylation in cervical carcinoma
| Â | Â | Â | Gene | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Specimen type | No. studied | Any gene | CDH1 | DAPK | RARB | HIC1 | FHIT | RASSF1A | APC | CDKN2A | MGMT | BRCA1 | TP73 | TIMP3 | GSTP1 | MLH1 |
Controls | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CC cell lines | 8 | 8 (100) | 1 (12.5) | 2 (25) | 6 (75) | 5 (62.5) | 1 (12.5) | 3 (37.5) | 0 | 1 (12.5) | 2 (25) | 0 | 2 (25) | 0 | 1 (12.5) | 1 (12.5) |
Primary tumors | 82 | 71 (86.6) | 45 (54.9) | 37 (45.1) | 24 (29.3) | 15 (18.3) | 9 (11) | 6 (7.3) | 9 (11) | 7 (8.5) | 4 (4.9) | 5 (6.1) | 0 | 1 (1.2) | 0 | 0 |