Figure 1

Effect of STI571 on pancreatic cancer cell lines. Aspc-1, BxPc-3, Capan-1, Colo-357, Mia-PaCa-2 and T3M4 cells were cultured in medium containing 1% FCS (open triangle) or 10% FCS (solid circle) and incubated in the absence (0) or presence of increasing concentrations of STI571 for 48 hours. Cell growth was determined by the MTT assay. Percent growth inhibition was calculated by comparison with control cell growth. Values shown are the mean ± SEM obtained from three independent experiments.