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Table 1 Angiogenesis modulating biomarker status in various prostate archival specimens. (n= 42)

From: Expression of biomarkers modulating prostate cancer angiogenesis: Differential expression of annexin II in prostate carcinomas from India and USA

Antigen BPH Atrophy PIN MD PCa PD PCa Stroma
Annexin II +(3) ++(4)* ++(2)* -(4) -(3) +(4)
Cyclooxygenase-2 +(4) +(4) ++(3)* +(2) +(1) ++(2)*
Decorin -(4) -(4) ++(2)* -(4) -(4) +++(4)*
Versican ++(4) + (4) +(2) + (3) ++(1) +(3)
CD34 -(4) +(4) ++(3)* +(1) ++(3)* ND
  1. $ Benign Prostatic Hyperplasia (BPH), high-grade Prostatic Intraepithelial Neoplasia (PIN), moderately-differentiated prostate adenocarcinoma (MD PCa), poorly-differentiated prostate adenocarcinoma (PD PCa), not determined (ND). Staining Intensity was scored as negative(-), weak (+), moderate (++) or strong (+++). Average percentage of cells were estimated and placed empirically into four categories 1–25%, 26–50%, 51–75%, or 75–100% and denoted in parenthesis as (1), (2), (3) or (4) respectively. The combination factor (product) of staining intensity and percentage of cells was used for statistical significance analysis of the data. Significant correlation is denoted as '*' for p≤ 0.05. The 95 % confidence limits for correlation coefficient were negative for Anx-II (0.015) and positive for COX-2 (0.019) expression in PCa.