Table 1 Summary of experimental modulation of growth factors in the treatment of pancreatic cancer
From: Implications of growth factor alterations in the treatment of pancreatic cancer
Target molecule | Applied agent | Effects | Cancer cells / mouse modells | Reference |
|---|---|---|---|---|
EGF-R | PKI 166 (+gemcitabine) | inhibition of lymph node and liver metastases and angiogenesis | L3.6pl | 44 |
VEGF-R | adenovirus vectors encoding soluble flt-1 | suppression of tumour growth, angiogenesis and MVD, increase of apoptosis | PANC-1 and PK-8 | 48 |
EGF-R, VEGF-R, PDGF-R | SU6668 (+irradiation) | suppression of tumour growth and tumour blood flow | A/J mice, C3H mice, Balb/cAnNCrl-nuBr nude mice | 50 |
HGF | NK4 | inhibition of tumour growth, peritoneal dissemination, ascites accumulation | SUIT-2 | 55 |