Figure 2
From: Role of promoter hypermethylation in Cisplatin treatment response of male germ cell tumors
Comparisons of promoter hypermethylation frequencies in different phases of treated patients with GCTs. Phase definitions are shown in Table 1. P, untreated primary tumor; M1, untreated metastatic tumor; C1, one regimen of chemotherapy; C2/C3, two or more regimens of chemotherapy. Promoter methylation of RASSF1A, HIC1, and APC genes was significantly high in resistant tumors. The MGMT, BRCA1, and RARB genes show higher frequency of promoter methylation in tumors exposed to one cycle of chemotherapy.