Figure 3
From: Role of promoter hypermethylation in Cisplatin treatment response of male germ cell tumors
Promoter methylation changes in vitro in GCT cell lines. Appearance of de novo promoter hypermethylation in cell lines. T, tumor; CL, cell line; CDDP, cisplatin-treated cell line. M, methylated DNA; U, unmethylated DNA; Cell lines examined are shown below. Note absence of methylation in primary tumor in both the cell lines and appearance of novel methylated allele in cell line DNA. Note both alleles of RASSF1A are methylated in 218A cell line.