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Table 2 Frequency of promoter methylation of individual genes in sensitive and resistant NSGCT

From: Role of promoter hypermethylation in Cisplatin treatment response of male germ cell tumors

Gene

Sensitive1 (N = 29) (%)

Resistant2 (N = 31) (%)

P-value

APC

7 (24)

9 (29)

0.77

BRCA13

9 (31)

9 (30)

1.0

ECAD

1 (3)

2 (6)

1.0

FANCF

2 (7)

2 (6)

1.0

FHIT

2 (7)

2 (6)

1.0

HIC13

7 (24)

14 (47)

0.10

MGMT

9 (31)

4 (13)

0.12

RARB

4 (14)

0

0.05

RASSF1A

8 (28)

16 (52)

0.07

  1. 1 Consists of tumors, with or without retroperitoneal lymph node, sensitive for one cycle of chemotherapy 2 Consists of tumors, with or without retroperitoneal lymph node, required of two or more cycles of chemotherapy, all resistant tumors, and all patients died of disease 3 Only 30 resistant tumors studied for methylation status
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Molecular Cancer

ISSN: 1476-4598