Figure 2
From: PTTG/securin activates expression of p53 and modulates its function
Overexpression of PTTG activates p53 gene promoter and expression. MCF7, PC3 and HEK293 cells were co-transfected with the p53 gene promoter and PTTG expression vectors. The fold increases in luciferase activity on transfection of cells with PTTG expression vector (solid bars) compared to cells transfected with vector only (open bars) is shown. Transfections were performed in duplicate and the results are expressed as mean ± S.E.M of four independent experiments (*, p < 0.05 by Student's t-test).