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Table 3 List of the significantly down-regulated genes in the MPNSTs relative to the plexiform neurofibromas

From: Molecular profiling of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1, based on large-scale real-time RT-PCR

GENES Gene definition Gene caracterisation Plexiform neurofibromas (n = 14) MPNSTs (n = 9) P1 ROC-AUC2
ITGB4 Integrin beta 4 Adhesion molecule 0.74 [0.19–3.46]3 0.01 [0.00–0.03] <0.01 1.000
CMA1 Chymase 1 Mast cell-specific marker 0.42 [0.04–4.62] 0.01 [0.00–0.03] <0.01 1.000
L1CAM L1 cell adhesion molecule Schwann cell-specific marker 0.32 [0.04–1.26] 0.00 [0.00–0.03] <0.01 1.000
MPZ Myelin protein zero Schwann cell-specific marker 0.43 [0.08–3.43] 0.01 [0.00–0.02] <0.01 1.000
DHH Desert hedgehog homolog Hedgehog signalling pathway 0.84 [0.12–10.8] 0.05 [0.01–0.15] <0.01 0.992
S100B S100 calcium binding protein, beta Schwann cell-specific marker 0.77 [0.14–3.03] 0.01 [0.00–0.17] <0.01 0.992
ERBB3 ErbB3 Growth factor receptor 0.49 [0.06–2.31] 0.01 [0.00–0.21] <0.01 0.984
PTCH2 Patched homolog 2 Hedgehog signalling pathway 0.95 [0.07–4.66] 0.05 [0.01–0.24] <0.01 0.980
RASSF2 Ras association domain family 2 Signal transduction 1.11 [0.23–11.1] 0.04 [0.01–0.35] <0.01 0.976
TPSB Tryptase beta 1 and 2 Mast cell-specific marker 0.96 [0.03–2.57] 0.04 [0.01–0.07] <0.01 0.952
SOX10 SRY (sex determinig region Y)-box10 Schwann cell-specific marker 0.26 [0.00–1.18] 0.01 [0.00–0.05] <0.01 0.929
TIMP4 Tissue inhibitor 4 of MMP Extracellular matrix remodeling 0.69 [0.02–11.5] 0.03 [0.01–0.27] <0.01 0.917
  1. 1Mann and Whitney's U Test 2ROC (Receiver Operating Characteristics) – AUC (Area Under Curve) analysis 3Median [range] of gene mRNA levels