Molecular profiling of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1, based on large-scale real-time RT-PCR

Table 3 List of the significantly down-regulated genes in the MPNSTs relative to the plexiform neurofibromas

GENES	Gene definition	Gene caracterisation	Plexiform neurofibromas (n = 14)	MPNSTs (n = 9)	P¹	ROC-AUC²
ITGB4	Integrin beta 4	Adhesion molecule	0.74 [0.19–3.46]³	0.01 [0.00–0.03]	<0.01	1.000
CMA1	Chymase 1	Mast cell-specific marker	0.42 [0.04–4.62]	0.01 [0.00–0.03]	<0.01	1.000
L1CAM	L1 cell adhesion molecule	Schwann cell-specific marker	0.32 [0.04–1.26]	0.00 [0.00–0.03]	<0.01	1.000
MPZ	Myelin protein zero	Schwann cell-specific marker	0.43 [0.08–3.43]	0.01 [0.00–0.02]	<0.01	1.000
DHH	Desert hedgehog homolog	Hedgehog signalling pathway	0.84 [0.12–10.8]	0.05 [0.01–0.15]	<0.01	0.992
S100B	S100 calcium binding protein, beta	Schwann cell-specific marker	0.77 [0.14–3.03]	0.01 [0.00–0.17]	<0.01	0.992
ERBB3	ErbB3	Growth factor receptor	0.49 [0.06–2.31]	0.01 [0.00–0.21]	<0.01	0.984
PTCH2	Patched homolog 2	Hedgehog signalling pathway	0.95 [0.07–4.66]	0.05 [0.01–0.24]	<0.01	0.980
RASSF2	Ras association domain family 2	Signal transduction	1.11 [0.23–11.1]	0.04 [0.01–0.35]	<0.01	0.976
TPSB	Tryptase beta 1 and 2	Mast cell-specific marker	0.96 [0.03–2.57]	0.04 [0.01–0.07]	<0.01	0.952
SOX10	SRY (sex determinig region Y)-box10	Schwann cell-specific marker	0.26 [0.00–1.18]	0.01 [0.00–0.05]	<0.01	0.929
TIMP4	Tissue inhibitor 4 of MMP	Extracellular matrix remodeling	0.69 [0.02–11.5]	0.03 [0.01–0.27]	<0.01	0.917

¹Mann and Whitney's U Test ²ROC (Receiver Operating Characteristics) – AUC (Area Under Curve) analysis ³Median [range] of gene mRNA levels

ISSN: 1476-4598