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Table 2 A highly selective list of gene specific probes that are differentially expressed (P < 0.005) between MSI-H and MSS colorectal cancers with a fold-change of at least 1.5.

From: Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity

Genes Up-regulated in MSI-H Colorectal Cancer

Gene name

P value

Fold change

Catenin (cadherin assoc. protein) beta 1

6.5 × 10-12

2.9

Interleukin 8*

1.7 × 10-4

2.8

Granulysin*

1.3 × 10-7

2.8

Caspase 2*

6.0 × 10-8

2.4

Interleukin 24

0.004

2.3

Heat shock protein (HSP 110 family)*

2.4 × 10-5

2.2

TP53 (Li Fraumeni)*

2.5 × 10-4

2.2

Toll-like receptor 2 (TLR-2)

1.9 × 10-4

1.9

Heat shock protein 70*

3.5 × 10-6

1.8

Granzyme A

0.001

1.7

Interleukin 1β

0.004

1.7

Survivin

0.001

1.6

Calreticulin

2.9 × 10-5

1.6

Human Natural killer Cell enhancing factor

0.001

1.6

CD68 antigen

4.8 × 10-4

1.6

ICAM 1 (CD54)

0.003

1.6

Interleukin 18 (interferon-gamma inducing factor)*

0.003

1.5

Interleukin 7

4.6 × 10-4

1.5

Interleukin 15*

0.002

1.5

Genes down-regulated in MSI-H colorectal cancer

Gene name

P value

Fold change

Insulin-like growth factor 2 (somatomedin A)

1.9 × 10-5

4.3

TGFβ RII

9.3 × 10-5

3.0

hMLH 1*

6.7 × 10-5

2.4

  1. P values denote results of Welch's t test with Benjamini and Hochberg False Discovery Rate. * denotes genes selected for RT-PCR analysis.