Table 2 Bivariate correlation between two-transcript abundance ratios and chemoresistance in a validation set of NSCLC cell lines. The ratios best correlated with chemoresistance from Additional file 2 were evaluated in an additional six lines. The effect of adding a second variable into the model was assessed. ERCC2/XPC was no longer correlated with chemoresistance and ABCC5/XPC had substantially lower p value. The other single variable models and the two variable model were validated.

Model r ²

p value

Model r ²

p value

0.91

0.0002

0.69

0.0002

0.91

0.0002

0.88

0.0001

0.90

0.0003

NS^c

0.90

0.0004

0.63

0.0007

0.89

0.0004

0.62

0.0008

0.88

0.0005

0.75

0.0001

0.88

0.0006

0.29

0.0461

Model r ²

p value

Model r ²

p value

0.96

0.0003

0.91

0.0001