Table 1 Significantly regulated genes in SMC3 overexpressing 293 cells. Human expressed sequence tags and genes with no known function are not included. Complete results of the array have been submitted to the EBI microarray database.

Bamacan/SMC3

2.06

2.04

Extracellular Matrix

GPC3, glypican 3

2.55

2.49

lectin, mannose-binding, 1 like

2.05

2.13

HAS2, hyaluronan synthase 2

1.89

2.03

LAMB3, lamin, beta 3

-1.99

-3.76

Transporter and ion channels

ATP6V1B1, ATPase, H⁺ transporting V1 subunit B, kidney isoform

3.15

2.40

KCTD12, potassium channel tetramerisation domain 12

1.85

2.02

SLC7A10, solute carrier family 7 member 10, neutral amino acid transporter

-2.00

-2.00

Metabolism

MIG12, MID1 interacting G12-like protein

2.58

2.65

CKB, creatine kinase, B chain

2.00

2.28

ECHDC3, enoyl Coenzyme A hydratase domain containing 3

2.25

2.20

ALDH1A3, aldehyde dehydrogenase 1 family, member A3

1.94

2.16

MOXD1, monooxygenase, DBH-like 1

2.53

2.05

TXNRD3, thioredoxin reductase 3

1.81

2.00

Growth factors and receptors

LTBP2, latent transforming growth factor beta binding protein 2

1.95

2.68

GABRE, gamma-aminobutyric acid A receptor, epsilon

2.04

2.54

DLL1, delta-like 1, notch ligand

1.83

2.23

GDF9, growth differentiation factor 9

1.88

2.19

IGFBP7, insulin-like growth factor binding protein 7

1.81

2.15

GNRH1, gonadotropin-releasing hormone 1

2.23

2.04

IRAK1, interleukin-1 receptor associated kinase 1

-2.17

-2.13

EGFL3, EGF-like-domain, multiple 3

-2.20

-2.16

IL22RA1, interleukin 22 receptor, alpha 1

-2.22

-2.48

OR4D1, olfactory receptor, family 4, subfamily D, member 1

-1.91

-3.03

GRB7, growth factor receptor-bound protein 7

-2.20

-4.18

Signal Transduction

ARHGEF4, Rho guanine nucleotide exchange factor 4

2.36

2.85

RGS14, regulator of G-protein signaling 14

2.17

2.57

RPS6KA5, ribosomal protein S6 kinase, polypeptide 5

2.09

2.46

PAK6, p21-activated kinase 6

2.16

2.38

RIN3, Ras and Rab interactor 3

1.86

2.19

RHOB, ras homolog gene family, member B

1.81

2.18

SCFD1, sec1 family domain containing 1

2.31

2.08

LRRK1, leucine-rich repeat kinase 1

2.16

2.06

RAB40B, GTP-binding protein 40B

1.91

2.15

PDE6B, phosphodiesterase 6B, cGMP-specific

2.02

2.09

MCF2L, MCF.2 cell line derived transforming sequence

-1.92

-2.16

S100A8, S 100 calcium binding protein A8, calgranulin A

-1.92

-2.86

ADCY2, adenylate cyclase 2

-1.92

-3.03

Transcriptional factors

MEOX2, mesenchyme homeobox 2, growth arrest specific homeobox

2.14

3.96

IRF4, interferon regulatory factor 4

2.20

3.28

KHDRBS3, KH domain, RNA binding, signal transduction associated 3

2.24

2.62

PPARA, peroxisome proliferative activated receptor, alpha

2.22

2.50

CRE-BPa, cAMP responsive element binding protein, ATF2-like

1.94

2.37

NEK9, never-in-mitosis-gene a-related kinase 9

1.83

2.33

CREM, cAMP responsive element modulator

-1.87

-2.11

NCOA6, nuclear receptor coactivator 6

-1.88

-2.32

TXB21, T-box 21

-1.88

-2.42

POU3F1, POU domain, class 3, octamer-binding TF6

-2.21

-2.44

NKX6-1, NK6 transcriptional factor related, locus 1, homeobox 6A

-1.90

-2.53

CTNNA1, catenin alpha 1

-1.90

-2.57

BCL6B, B-cell CLL/lymphoma 6, member B zinc finger protein

-2.72

-2.79

ZNF236, zinc finger protein 236

-1.90

-3.11

DNA repair, gene transcription

MHL3, mutL homolog 3

2.76

2.81

DNMT2, DNA cytosine-5-methyltransferase 2

1.88

2.07

ADPRTL2, ADP-ribosyltransferase 2

2.11

2.00

SNRPN, small nuclear ribonuclear polypeptide N

-2.25

-2.64

Various

MYOM2, myomesin 2

2.77

5.10

NOPE, neighbor of Punc E11

2.53

2.56

C5, complement component 5

2.09

2.46

COCH, coagulation factor C homolog, cochlin

2.15

2.09

VMD2L1, vitelliform macular dystrophy 2-like 1

-2.17

-2.09

GRN, granulin

-1.94

-2.14

HPN, hepsin serine protease

-2.02

-2.27

LPHN1, latrophilin 1

-1.90

-2.38

PRND, prion protein 2

-2.01

-2.50

HYPM, huntingtin interacting protein M

-2.18

-3.98