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Table 1 Effect of FAK siRNA and β1 integrin blocking on apoptosis of pancreatic cancer cells

From: Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation

  Apoptotic fraction (%)
Cell line Untreated Anti-β1 integrin antibody FAK siRNA Control siRNA
AsPC-1 1.37 ± 0.33 1.89 ± 0.51 2.20 ± 0.66 1.44 ± 0.54
BxPC-3 1.99 ± 0.31 2.38 ± 0.51 2.56 ± 0.53 2.02 ± 0.4
Capan-2 2.44 ± 0.30 2.59 ± 0.37 3.01 ± 0.52 2.50 ± 0.43
  1. AsPC-1, BxPC-3, and Capan-2 cells were treated with anti-β1 integrin antibody, FAK siRNA, or control siRNA and incubated for 24 h, and then detection of apoptosis was performed by TUNEL assay and flow cytometry. Statistical significance was tested by one-way analysis of variance and post hoc test (Turkey Kramer multiple comparisons). All data are expressed as mean ± s.d. There was no significant difference among these treatments.