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Table 5 Genes significantly decreased in tumors.

From: Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome

GeneBank Accession Gene Description Symbol Normal Mean Tumor Mean Fold Change P value
  Cell Growth/Division      
D17291 regenerating protein I beta REG1B 6286 13 -499.46 0.000095
X67318 carboxypeptidase A1 CPA1 3928 121 -32.57 0.003205
AI763065 regenerating islet-derived 1 alpha REG1A 5641 334 -16.88 0.000001
D29990 solute carrier family 7, member 2 SLC7A2 2988 445 -6.72 0.002204
AB017430 kinesin-like 4 KIFF22 1223 316 -3.87 0.000177
Z25884 chloride channel 1 CLCN1 2511 655 -3.84 0.00013
X81438 amphiphysin AMPH 2686 752 -3.57 0.000002
L03785 myosin, light polypeptide 5 MYL5 207 59 -3.51 0.000233
W28062 guanine nucleotide-exch. Prot. 2 ARFGEF2 66 19 -3.46 0.003602
X52486 uracil-DNA glycosylase 2 UNG2 2555 756 -3.38 0.000514
M81933 cell division cycle 25A CDC25A 312 96 -3.25 0.000005
M69136 chymase 1 CMA1 360 115 -3.13 0.004413
U90543 butyrophilin BTN2A1 685 226 -3.04 0.000023
X69086 utrophin UTRN 1325 457 -2.90 0.000011
AF039241 histone deacetylase 5 HDAC5 1124 393 -2.86 0.000319
U49392 allograft inflammatory factor 1 AIF1 165 58 -2.82 0.000105
U81992 pleiomorphic adenoma gene-like 1 PLAGL1 330 118 -2.80 0.004717
L26336 heat shock 70kD protein 2 HSPA2 90 32 -2.79 0.000689
F27891 cytochrome c oxidase subunit VIa COX6A2 872 313 -2.79 0.000342
D87673 heat shock transcription factor 4 HSF4 1964 721 -2.73 0.000453
X97795 RAD54-like RAD54L 392 144 -2.72 0.001345
X92689 UDP-N-acetyl-alpha-D-galactosamine GALNT3 80 32 -2.50 0.000243
Y08683 carnitine palmitoyltransferase I CPT1B 1038 420 -2.47 0.000573
U40622 X-ray repair complementing defective repair 4 XRCC4 177 72 -2.45 0.000678
U64315 excision repair, complementation group 4 ERCC4 2122 868 -2.44 0.000045
AB020337 beta 1,3-galactosyltransferase B3GALT5 1489 635 -2.34 0.002613
U40152 origin recognition complex ORC1L 3671 1702 -2.16 0.001425
M10943 metallothionein 1F MT1F 5691 2653 -2.14 0.001707
X79882 major vault protein MVP 758 376 -2.02 0.001719
AF035960 transglutaminase 5 TGM5 3097 1542 -2.01 0.002951
  Cell Death/Apoptosis      
S81914 immediate early response 3 IER3 2209 480 -4.60 0.000307
D80007 programmed cell death 11 PDCD11 457 129 -3.55 0.002358
AF013956 chromobox homolog 4 CBX4 1599 492 -3.25 0.00034
U33284 protein tyrosine kinase 2 beta PTK2B 693 237 -2.93 0.000763
U90919 likely partner of ARF1 APA1 2687 1021 -2.63 0.000015
X57110 Cas-Br-M retroviral transforming CBL 1889 784 -2.41 0.000033
AL050161 pro-oncosis receptor PORIMIN 1178 497 -2.37 0.00031
U40380 presenilin 1 PSEN1 1301 569 -2.29 0.00012
D83699 harakiri, BCL2 interacting protein HRK 768 338 -2.27 0.001321
U07563 v-abl viral oncogene homolog 1 ABL1 1415 631 -2.24 0.000248
M95712 v-raf oncogene homolog B1 BRAF 338 157 -2.16 0.004207
M16441 lymphotoxin alpha LTA 2106 985 -2.14 0.000239
AF035444 pleckstrin homology-like domain, family A, member 2 PHLDA2 334 166 -2.01 0.001759