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Figure 2 | Molecular Cancer

Figure 2

From: Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression

Figure 2

Analysis of methylation of Slit-Robo pathway genes in cervical cancer cell lines and primary tumors. A. MSP analysis. U, unmethylated; M, methylated. T, tumor. B. Concomitant hypermethylation of more than one Slit-Robo genes in primary cervical cancer. Frequency of number of genes methylated is shown. C. Sequence analysis of MSP products of SLIT1 and SLIT2 genes. SLIT2 sequences were derived from cloning of PCR products and SLIT1 was direct sequencing of MSP products. T, tumor; pap, cytologic smear. CpG sites are underlined. Unconverted sequence is shown above chromatogram for each gene. D. Number of Slit-Robo genes methylated in various stages of invasive cervical cancer.

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Molecular Cancer

ISSN: 1476-4598