Inhibition of tumor growth by celecoxib and DMC in vivo. Nude mice were implanted subcutaneously with U87 glioblastoma cells, and two weeks later received daily chow supplemented with celecoxib, DMC, or no drug. Shown here is the increase in tumor volume over time (mean ± SD; n = 8). At the end of the experiment, the difference in mean tumor volume between the non-treated groups and the groups receiving celecoxib or DMC was statistically significant (p < .01 and p < .003, respectively). Shown are two independent experiments that were performed at different times with different batches of U87 cells and different shipments of animals; therefore, a direct comparison between animals that received celecoxib and animals that received DMC is not possible.