Table 2 Associations between BRAF mutation and molecular features of colorectal cancer.
Feature (n) a | BRAF wild-type (%) | BRAF mutation (%) | P |
|---|---|---|---|
Total (275) | 252 (92) | 23 (8) | |
MSI | |||
negative (204) | 195 (96) | 9 (4) | |
positive (31) | 19 (61) | 12 (39) | <0.0001 |
Methylation status | |||
CIMP- (150) | 145 (97) | 5 (3) | |
CIMP+ (42) | 31 (74) | 11 (26) | <0.0001 |
MLH1 distal region | |||
Negative (168) | 159 (95) | 9 (5) | |
Positive (24) | 17 (71) | 7 (29) | <0.0001 |
MLH1 proximal region | |||
Negative (179) | 169 (94) | 10 (6) | |
Positive (13) | 7 (54) | 6 (46) | <0.0001 |
KRAS | |||
Wild-type (156) | 134 (86) | 22 (14) | |
Mutant (93) | 93 (100) | 0 (0) | <0.0001 |
TP53 | |||
Wild-type (183) | 166 (91) | 17 (9) | |
Mutant (66) | 62 (94) | 4 (6) | NS |