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Table 2 Associations between BRAF mutation and molecular features of colorectal cancer.

From: BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status

Feature (n) a BRAF wild-type (%) BRAF mutation (%) P
Total (275) 252 (92) 23 (8)  
MSI    
   negative (204) 195 (96) 9 (4)  
   positive (31) 19 (61) 12 (39) <0.0001
Methylation status    
   CIMP- (150) 145 (97) 5 (3)  
   CIMP+ (42) 31 (74) 11 (26) <0.0001
   MLH1 distal region    
   Negative (168) 159 (95) 9 (5)  
   Positive (24) 17 (71) 7 (29) <0.0001
   MLH1 proximal region    
   Negative (179) 169 (94) 10 (6)  
   Positive (13) 7 (54) 6 (46) <0.0001
KRAS    
   Wild-type (156) 134 (86) 22 (14)  
   Mutant (93) 93 (100) 0 (0) <0.0001
TP53    
   Wild-type (183) 166 (91) 17 (9)  
   Mutant (66) 62 (94) 4 (6) NS
  1. a Data was unavailable for MSI status in 40 cases, methylation status in 83 cases, KRAS mutation in 26 cases and TP53 mutation in 26 cases