Table 3 Clinicopathological and molecular features of BRAF mutant colorectal cancers stratified according to microsatellite instability status.
MSI- | MSI+ | |||||
|---|---|---|---|---|---|---|
Feature | BRAF WT (n = 192) (%) | BRAF M (n = 9) (%) | P | BRAF WT (n = 19) (%) | BRAF M (n = 12) (%) | P |
Age (years) | 68.5 ± 12.6 | 58.2 ± 26.5 | NS | 67.5 ± 16.8 | 76.1 ± 10.9 | NS |
Females | 39 | 44 | NS | 63 | 75 | NS |
TILS + a | 3 | 44 | 0.0004 | 28 | 60 | 0.08 |
Node negative | 62 | 62 | NS | 81 | 89 | NS |
Proximal site | 36 | 67 | 0.05 | 72 | 89 | NS |
Poor grade | 15 | 40 | 0.12 | 25 | 56 | 0.11 |
Mucinous | 12 | 53 | 0.05 | 6 | 44 | 0.04 |
CIMP+ | 15 | 50 | 0.03 | 40 | 88 | 0.03 |
Dist. MLH1 methylated | 7 | 12 | NS | 40 | 75 | 0.10 |
Prox. MLH1 methylated | 1 | 0 | NS | 33 | 75 | 0.06 |
KRAS mutant | 43 | 0 | 0.008 | 21 | 0 | 0.12 |
TP53 mutant | 29 | 11 | NS | 5 | 18 | NS |