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Table 3 Clinicopathological and molecular features of BRAF mutant colorectal cancers stratified according to microsatellite instability status.

From: BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status

  MSI-   MSI+  
Feature BRAF WT (n = 192) (%) BRAF M (n = 9) (%) P BRAF WT (n = 19) (%) BRAF M (n = 12) (%) P
Age (years) 68.5 ± 12.6 58.2 ± 26.5 NS 67.5 ± 16.8 76.1 ± 10.9 NS
Females 39 44 NS 63 75 NS
TILS + a 3 44 0.0004 28 60 0.08
Node negative 62 62 NS 81 89 NS
Proximal site 36 67 0.05 72 89 NS
Poor grade 15 40 0.12 25 56 0.11
Mucinous 12 53 0.05 6 44 0.04
CIMP+ 15 50 0.03 40 88 0.03
Dist. MLH1 methylated 7 12 NS 40 75 0.10
Prox. MLH1 methylated 1 0 NS 33 75 0.06
KRAS mutant 43 0 0.008 21 0 0.12
TP53 mutant 29 11 NS 5 18 NS
  1. aTumor-infiltrating lymphocytes