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Table 4 Clinicopathological and molecular features of BRAF mutant colorectal cancers stratified according to methylator phenotype status.

From: BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status

  CIMP-   CIMP+  
Feature BRAF WT (n = 145) (%) BRAF M (n = 5) (%) P BRAF WT (n = 31) (%) BRAF M (n = 11) (%) P
Age (years) 68.3 ± 13.5 71.0 ± 11.0 NS 71.7 ± 11.8 65.4 ± 26.3 NS
Females 37 60 NS 42 45 NS
TILS + 2 40 0.008 17 45 0.06
Node negative 63 60 NS 65 82 NS
Proximal site 35 60 NS 74 80 NS
Poor grade 13 66 0.05 20 40 NS
Mucinous 9 25 NS 25 45 NS
MSI+ 6 20 NS 19 64 0.01
Dist. MLH1 methylated 3 0 NS 42 64 NS
Prox. MLH1 methylated 0 0 NS 23 55 0.05
KRAS mutant 43 0 0.06 55 0 0.001
TP53 mutant 26 0 NS 29 20 NS