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Figure 5 | Molecular Cancer

Figure 5

From: Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors

Figure 5

Effect of glycoconjugates on mesothelin-MUC16 interaction. (A) Binding of meso-Fc to OVCAR-3 cells was measured in the presence of 0.25 mM N-acetylglucosamine (GlcNAc) or N-acetyllactosamine (LacNAc) by flow cytometry. (B and C) Similarly the effect of ovomucoid (B) and ovotransferrin (C) on meso-Fc binding to OVCAR-3 was measured using the same technique. Meso-Fc binding was monitored by using the GAR-FITC reporter antibody.

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