Figure 6
From: Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis
Neutralization of CXCL12 in animals bearing orthotopic human RCC tumors resulted in attenuated metastasis to specific organs. SCID mice bearing orthotopic xenoengraftment of either SN12C-VC or SN12C-VHL-KD cells were subjected to intraperitoneal injection of anti-CXCL12 antibodies or preimmune serum as a control. Six animals were included in each treatment group. Data are expressed as the percentage of GFP+ cells found in each organ examined by FACS analysis. Data represent mean ± SEM.