Table 1 Proteins from our proteomic analysis which were significantly different in ccRCC as compared to normal kidney tissue.
From: Pathway analysis of kidney cancer using proteomics and metabolic profiling
Symbol | Protein Name | SwissProt ID | Entrez Gene ID | Ratio RCC: normal kidney | Minimum Paired t-test |
|---|---|---|---|---|---|
SUCLG1 | succinate-CoA ligase, GDP-forming, alpha subunit | P53597 | 8802 | 0.2 | 0.0000 |
HSPCB | heat shock 90kDa protein 1, beta | P08238 | 3326 | 0.4 | 0.0001 |
ALDOB | aldolase B, fructose-bisphosphate | P05062 | 229 | 0.1 | 0.0001 |
PRDX1 | peroxiredoxin 1 | Q06830 | 5052 | 0.3 | 0.0002 |
ECHS1 | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | P30084 | 1892 | 0.3 | 0.0002 |
GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | P50440 | 2628 | 0.3 | 0.0003 |
ASS | argininosuccinate synthetase | P00966 | 445 | 0.3 | 0.0008 |
ATP5H | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d | O75947 | 10476 | 0.4 | 0.0010 |
HSPD1 | heat shock 60kDa protein 1 (chaperonin) | P10809 | 3329 | 0.4 | 0.0019 |
ATP5D | ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit | P30049 | 513 | 0.3 | 0.0029 |
PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | Q16822 | 5106 | 0.3 | 0.0033 |
CALB1 | calbindin 1, 28kDa | P05937 | 793 | 0.3 | 0.0035 |
BHMT | betaine-homocysteine methyltransferase | Q93088 | 635 | 0.5 | 0.0041 |
ACY1 | aminoacylase 1 | Q03154 | 95 | 0.4 | 0.0043 |
AKR1A1 | aldo-keto reductase family 1, member A1 (aldehyde reductase 2ALR) | P14550 | 10327 | 0.4 | 0.0054 |
AGMAT | agmatine ureohydrolase (agmatinase) | Q9BSE5 | 79814 | 0.5 | 0.0064 |
ACAT1 | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | P24752 | 38 | 0.4 | 0.0078 |
GSTO2 | glutathione-S-transferase, alpha-class, omega 2 subunit | P08263 | 119391 | 0.4 | 0.0101 |
PKM2 | pyruvate kinase, muscle | P14618 | 5315 | 14.7 | 0.0170 |
ANXA4 | annexin A4 | Q6P452 | 307 | 2.7 | 0.0225 |
ANXA5 | Annexin V | P08758 | 308 | 2.3 | 0.0245 |
HSPB1 | heat shock 27kDa protein 1 | P04792 | 3315 | 2.4 | 0.0256 |
FABP7 | fatty acid binding protein 7, brain | O15540 | 2173 | 6.3 | 0.0262 |
TBB2 | tubulin, beta polypeptide | P07437 | 7280 | 19.5 | 0.0264 |
ENO2 | enolase 2, (gamma, neuronal) | P09104 | 2026 | 32.8 | 0.0364 |
LDHA | lactate dehydrogenase A | P00338 | 3939 | 3.8 | 0.0383 |
CLIC1 | chloride intracellular channel 1 | O00299 | 1192 | 2.8 | 0.0414 |
GAPDH | glyceraldehyde-3-phosphate dehydrogenase | P04406 | 2597 | 2.1 | 0.0450 |
PSME2 | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | Q9UL46 | 5721 | 2.2 | 0.0460 |
CSTB | cystatin B (stefin B) | P04080 | 1476 | 4.0 | 0.0464 |
HINT1 | histidine triad nucleotide binding protein 1 (PKCi substrate analog) | P49773 | 3094 | 2.4 | 0.0482 |