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Table 1 Proteins from our proteomic analysis which were significantly different in ccRCC as compared to normal kidney tissue.

From: Pathway analysis of kidney cancer using proteomics and metabolic profiling

Symbol Protein Name SwissProt ID Entrez Gene ID Ratio RCC: normal kidney Minimum Paired t-test
SUCLG1 succinate-CoA ligase, GDP-forming, alpha subunit P53597 8802 0.2 0.0000
HSPCB heat shock 90kDa protein 1, beta P08238 3326 0.4 0.0001
ALDOB aldolase B, fructose-bisphosphate P05062 229 0.1 0.0001
PRDX1 peroxiredoxin 1 Q06830 5052 0.3 0.0002
ECHS1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial P30084 1892 0.3 0.0002
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) P50440 2628 0.3 0.0003
ASS argininosuccinate synthetase P00966 445 0.3 0.0008
ATP5H ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d O75947 10476 0.4 0.0010
HSPD1 heat shock 60kDa protein 1 (chaperonin) P10809 3329 0.4 0.0019
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit P30049 513 0.3 0.0029
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) Q16822 5106 0.3 0.0033
CALB1 calbindin 1, 28kDa P05937 793 0.3 0.0035
BHMT betaine-homocysteine methyltransferase Q93088 635 0.5 0.0041
ACY1 aminoacylase 1 Q03154 95 0.4 0.0043
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase 2ALR) P14550 10327 0.4 0.0054
AGMAT agmatine ureohydrolase (agmatinase) Q9BSE5 79814 0.5 0.0064
ACAT1 acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) P24752 38 0.4 0.0078
GSTO2 glutathione-S-transferase, alpha-class, omega 2 subunit P08263 119391 0.4 0.0101
PKM2 pyruvate kinase, muscle P14618 5315 14.7 0.0170
ANXA4 annexin A4 Q6P452 307 2.7 0.0225
ANXA5 Annexin V P08758 308 2.3 0.0245
HSPB1 heat shock 27kDa protein 1 P04792 3315 2.4 0.0256
FABP7 fatty acid binding protein 7, brain O15540 2173 6.3 0.0262
TBB2 tubulin, beta polypeptide P07437 7280 19.5 0.0264
ENO2 enolase 2, (gamma, neuronal) P09104 2026 32.8 0.0364
LDHA lactate dehydrogenase A P00338 3939 3.8 0.0383
CLIC1 chloride intracellular channel 1 O00299 1192 2.8 0.0414
GAPDH glyceraldehyde-3-phosphate dehydrogenase P04406 2597 2.1 0.0450
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) Q9UL46 5721 2.2 0.0460
CSTB cystatin B (stefin B) P04080 1476 4.0 0.0464
HINT1 histidine triad nucleotide binding protein 1 (PKCi substrate analog) P49773 3094 2.4 0.0482