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Table 1 Protein expression of stem cell markers and others in OGCTs

From: Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers

HISTOLOGY of core N N bilat OCT-3/4 NANOG KIT AP-2γ TSPY MAGE-A4 NY-ESO-1 AMH PLAP HCG AFP
OVARIAN TISSUES
Foetal GW 13–18 4   OCT-3/4 in foetal ovary: Ref [21] Neg KIT in foetal ovary: Ref [31] AP-2γ in foetal ovary: Ref [27] Neg Oogonia++ Oogonia+/- AMH in foetal ovary: Ref [19] n.a. n.a. n.a.
Foetal GW 20–24 4     Neg      Neg Oogonia++ Oogonia+/-    n.a. n.a. n.a.
Foetal GW 34–40 4     Neg      Neg Oogonia++ Oogonia+/-    n.a. n.a. n.a.
DG 17 4 ++/+- 80% ++ 67% ++/+ 80%** ++/+ 33% +- 13% ++/+- 40%    -   ++/+- 100% ++ 7% ++ 7%
DG (w/GB) ¤ 8 4 ++/+- 75% ++/+ 38% ++ 88%** +/+- 38% ++/+ 63% + 13% -   -   ++/+- 100% -   -  
GB 2 1 ++/+ 100% + 50% ++/+ 100%** -   ++ 50% -   -   -   ++ 100% -   -  
EC 1   -   + 100% -   -   -   -   -   -   ++ 100% -   -  
YST 14 1 + 8% + 15% +/+- 15% -   -   -   -   -   ++/+- 46% -   ++/+- 77%
IT 17   -   -   -   -   -   -   -   -   -   -   +- 6%
CC 1   -   -   -   -   -   -   -   -   -   ++ 100% -  
SCC 8   -   -   -   -   -   -   -   -   -   -   -  
NON-OVARIAN TISSUES
Adult normal testis 3   -   +- (unsp) + 100% -   ++ 100%|| + 100%|| + 33%†† ++ 100% -   -   -  
CIS testis 2   ++ 100% ++ 100% ++ 100% ++ 100% ++ 100% -   -   -   n.a.   n.a.   n.a.  
Seminoma testis 2   ++ 100% ++ 100% ++ 100% ++ 50% ++ 100% -   -   -   ++ 100% -   -  
EC/TER testis 2   ++ 100% ++ 100% + 50% ++/+ 100% + 100% -   -   -   ++/+ 100% ++ 100% + 50%
YST testis 1   ++ 100% ++ 100% -   -   -   -   -   -   + 100% ++ 100% ++ 100%
Colon cancer 2   -   -   -   -   -   -   -   -   -   -   -  
Prostate cancer 2   -   -   -   -   -   -   -   -   -   -   -  
Normal brain 1   -   -   -   -   -   -   -   -   -   -   -  
Normal kidney 1   -   -   - (unsp) - (unsp) +- (unsp) -   -   -   -   -   -  
Normal liver 2   -   -   - (unsp) - (unsp) -   -   -   -   -   -   -  
  1. Staining intensity is marked by '++'/'+'/'+-'/'-' followed by the percentage of positive tissue samples. Staining intensity = '++': >50%, of tumour cells stained; '+': staining in approximately 20–50% of tumour cells; '+-': few cells stained; '-': no positive cells detected. For each tumour type the range of staining intensities are divided with '/'. Symbols = : staining in spermatocytes; ||: staining in spermatocytes and spermatogonia; ††: staining in spermatogonia; : staining in pre-pubertal Sertoli cells; **: all bilateral DG or GB stained '++' with KIT; ¤: DG tissue from patients with diagnosis DG with GB. Abbreviations: OGCT = ovarian germ cell tumour; GW = gestational week; DG = dysgerminoma; GB = gonadoblastoma; EC = embryonal carcinoma; YST = yolk sac tumour; IT = immature teratoma; CC = choriocarcinoma; SCC = small cell carcinoma; CIS = carcinoma in situ; TER = teratoma; N = number; bilat = bilateral; n.a. = not analysed; ref = reference; unsp = unspecific.