Table 2 Top 20 significant GO groups in interaction analysis, sorted according to the weight algorithm
Rank (weight) | GO ID | GO Term definition | Annotated number of genes | Significant number of genes | Expected number of genes | Rank (classic) | p-value (classic) | p-value (weight) |
|---|---|---|---|---|---|---|---|---|
1 | GO:0006955 | immune response | 1241 | 57 | 26.05 | 2 | 1.50E-08 | 3.30E-05 |
2 | GO:0009607 | response to biotic stimulus | 1409 | 63 | 29.58 | 1 | 6.40E-09 | 5.30E-05 |
3 | GO:0030865 | cortical cytoskeleton organization and biogenesis | 22 | 5 | 0.46 | 8 | 7.80E-05 | 7.80E-05 |
4 | GO:0001766 | lipid raft polarization | 2 | 2 | 0.04 | 11 | 0.00044 | 0.00044 |
5 | GO:0006956 | complement activation | 49 | 6 | 1.03 | 15 | 0.00054 | 0.00054 |
6 | GO:0007155 | cell adhesion | 972 | 36 | 20.40 | 16 | 0.00067 | 0.00076 |
7 | GO:0009967 | positive regulation of signal transduction | 176 | 11 | 3.69 | 22 | 0.00125 | 0.00125 |
8 | GO:0009611 | response to wounding | 589 | 25 | 12.36 | 17 | 0.00070 | 0.00137 |
9 | GO:0045995 | regulation of embryonic development | 12 | 3 | 0.25 | 24 | 0.00175 | 0.00175 |
10 | GO:0042135 | neurotransmitter catabolism | 15 | 3 | 0.31 | 28 | 0.00346 | 0.00346 |
11 | GO:0043122 | regulation of I-kappaB kinase/NF-kappaB cascade | 149 | 9 | 3.13 | 29 | 0.00425 | 0.00425 |
12 | GO:0006952 | defense response | 1354 | 60 | 28.42 | 3 | 2.20E-08 | 0.00445 |
13 | GO:0009190 | cyclic nucleotide biosynthesis | 33 | 4 | 0.69 | 33 | 0.00483 | 0.00483 |
14 | GO:0050678 | regulation of epithelial cell proliferation | 17 | 3 | 0.36 | 34 | 0.00501 | 0.00501 |
15 | GO:0008354 | germ cell migration | 7 | 2 | 0.15 | 39 | 0.00861 | 0.00861 |
16 | GO:0009613 | response to pest, pathogen or parasite | 776 | 34 | 16.29 | 7 | 4.20E-05 | 0.01258 |
17 | GO:0016064 | humoral defense mechanism (sensu Vertebrata) | 165 | 10 | 3.46 | 25 | 0.00258 | 0.01310 |
18 | GO:0006024 | glycosaminoglycan biosynthesis | 24 | 3 | 0.50 | 46 | 0.01339 | 0.01339 |
19 | GO:0050672 | negative regulation of lymphocyte proliferation | 9 | 2 | 0.19 | 47 | 0.01435 | 0.01435 |
20 | GO:0008037 | cell recognition | 28 | 3 | 0.59 | 58 | 0.02038 | 0.02038 |