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Table 2 Top 20 significant GO groups in interaction analysis, sorted according to the weight algorithm

From: Factor interaction analysis for chromosome 8 and DNA methylation alterations highlights innate immune response suppression and cytoskeletal changes in prostate cancer

Rank (weight) GO ID GO Term definition Annotated number of genes Significant number of genes Expected number of genes Rank (classic) p-value (classic) p-value (weight)
1 GO:0006955 immune response 1241 57 26.05 2 1.50E-08 3.30E-05
2 GO:0009607 response to biotic stimulus 1409 63 29.58 1 6.40E-09 5.30E-05
3 GO:0030865 cortical cytoskeleton organization and biogenesis 22 5 0.46 8 7.80E-05 7.80E-05
4 GO:0001766 lipid raft polarization 2 2 0.04 11 0.00044 0.00044
5 GO:0006956 complement activation 49 6 1.03 15 0.00054 0.00054
6 GO:0007155 cell adhesion 972 36 20.40 16 0.00067 0.00076
7 GO:0009967 positive regulation of signal transduction 176 11 3.69 22 0.00125 0.00125
8 GO:0009611 response to wounding 589 25 12.36 17 0.00070 0.00137
9 GO:0045995 regulation of embryonic development 12 3 0.25 24 0.00175 0.00175
10 GO:0042135 neurotransmitter catabolism 15 3 0.31 28 0.00346 0.00346
11 GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade 149 9 3.13 29 0.00425 0.00425
12 GO:0006952 defense response 1354 60 28.42 3 2.20E-08 0.00445
13 GO:0009190 cyclic nucleotide biosynthesis 33 4 0.69 33 0.00483 0.00483
14 GO:0050678 regulation of epithelial cell proliferation 17 3 0.36 34 0.00501 0.00501
15 GO:0008354 germ cell migration 7 2 0.15 39 0.00861 0.00861
16 GO:0009613 response to pest, pathogen or parasite 776 34 16.29 7 4.20E-05 0.01258
17 GO:0016064 humoral defense mechanism (sensu Vertebrata) 165 10 3.46 25 0.00258 0.01310
18 GO:0006024 glycosaminoglycan biosynthesis 24 3 0.50 46 0.01339 0.01339
19 GO:0050672 negative regulation of lymphocyte proliferation 9 2 0.19 47 0.01435 0.01435
20 GO:0008037 cell recognition 28 3 0.59 58 0.02038 0.02038