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Table 2 Genes (n = 29) associated with colorectal carcinomatoses as compared to primary tumors and liver metastases.

From: Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses

Genebank Acc. Gene Symbol Gene Name Z-cut Fold change liver Fold change carcinomatoses Fold change primary Relative difference, carcinomatosis vs. primary
BC035498 CCNE1 cyclin E1 -3,59 -1.51 -2.15 1.05 2.24
AB011124 ProSAPiP1 ProSAPiP1 protein 3,24 1.37 2.26 1.28 1.77
NM_022772 EPS8L2 EPS8-like 2 -3,16 -1.64 -2.28 1.29 1.74
AK025824 EPS8L2 EPS8-like 2 -3,12 -1.63 -2.12 1.22 1.74
BC005245 C1orf41 chromosome 1 open reading frame 41 -3,07 -1.40 -2.63 -1.35 1.88
NM_017515 SLC35F2 solute carrier family 35, member F2 -2,89 -1.48 -2.75 -1.31 1.08
U73778 COL12A1 collagen, type XII, alpha 1 2,85 -1.72 2.34 1.15 1.77
BC004260 CAPN10 calpain 10 -2,85 4.54 -4.09 -2.34 2.03
NM_033018 PCTK1 PCTAIRE protein kinase 1 2,84 1.88 2.51 1.50 1.66
AK096896 ASB12 ankyrin repeat and SOCS box-containing 12 2,82 1.68 2.00 1.70 1.18
NM_033254 BOC brother of CDO 2,81 1.26 2.09 1.30 1.61
NM_018043 TMEM16A transmembrane protein 16A 2,78 -1.92 2.68 -1.84 5.08
BC012915 MPRP-1 metalloprotease related protein 1 -2,76 -1.70 -2.18 -1.57 1.39
BC002728 THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) -2,73 -1.41 -2.15 -1.23 1.73
X06482 HBQ1 hemoglobin, theta 1 2,71 1.69 2.61 1.28 2.09
X78947 CTGF connective tissue growth factor 2,65 2.32 3.94 1.85 2.22
AF067817 VAV3 vav 3 oncogene -2,63 -1.79 -2.50 -1.29 4.14
U86602 EBNA1BP2 EBNA1 binding protein 2 -2,63 -1.19 -4.81 -1.16 1.94
AL834404 NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -2,59 -1.96 -4.33 -1.47 2.93
M94065 DHODH dihydroorotate dehydrogenase -2,58 -1.63 -2.17 -1.04 2.08
NM_025109 MYOHD1 myosin head domain containing 1 -2,57 -1.68 -2.65 -1.03 2.55
NM_016234 ACSL5 acyl-CoA synthetase long-chain family member 5 -2,52 -2.52 -3.51 -1.52 2.07
NM_005132 REC8L1 REC8-like 1 (yeast) -2,50 -1.41 -2.15 -1.11 1.19
NM_003412 ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 2,47 -1.90 2.53 -1.43 2.97
BC007300 CHC1 chromosome condensation 1 -2,47 -1.66 -2.78 -1.81 1.70
NM_139160 DEPDC7 DEP domain containing 7 -2,46 -1.07 -3.07 -1.15 2.66
NM_015419 DKFZp564I1922 adlican 2,45 -2.51 3.54 1.82 1.96
M55905 ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial -2,41 -2.10 -3.72 -1.53 2.20
NM_017744 ST7L suppression of tumorigenicity 7 like -2,33 -1.56 -2.11 -1.28 1.54
  1. Z-cut is derived from BAMarray. Fold change; expression in fold change using medians of each group as compared to normal colonic tissue. Gene symbols in bold denote genes which are most dysregulated in the carcinomatosis cell line IS3, as compared to IS1 and IS2.