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Table 1 Differentially expressed genes in response to DDC overexpression*. The genes shown here are those whose expressions are increased (= 2) or decreased (= -2).

From: Androgen-regulated genes differentially modulated by the androgen receptor coactivator L-dopa decarboxylase in human prostate cancer cells

Genbank Acc

Gene Symbol & Name

DDC/CTRLs

Binding

BC016658

E2F7; E2F transcription factor 7

-13.60

AK024500

MICAL1; microtubule associated monoxygenase

+7.92

BC009212

MTA1; metastasis associated 1

+9.50

NM_032943

SYTL2; synaptotagmin-like 2

-2.02

AK027128

ZNF277; zinc finger protein 277

-3.88

AK054916

ZNF333; zinc finger protein 333

+4.67

AK056666

ZNF488; zinc finger protein 488

+6.76

Binding and catalytic activity

NM_019885

CYP26B1; cytochrome P450, family 26, subfamily B, polypeptide 1

+4.29

NM_022819

PLA2G2F; phospholipase A2, group IIF

+30.10

NM_004613

TGM2; transglutaminase 2

+2.10

AK022930

YME1L1; YME1-like 1 (S. cerevisiae)

+21.40

Binding and signal transducer activity

NM_000796

DRD3; dopamine receptor D3

-4.28

U92285

GABRE;Gamma-aminobutyric acid (GABA) A receptor, epsilon

+10.02

NM_004532

MUC4; mucin 4, tracheobronchial

-6.39

AF070577

OPCML; opioid binding protein/cell adhesion molecule-like

-3.87

NM_003728

UNC5C; unc-5 homolog C (C. elegans)

+18.48

Catalytic activity

  

AK055136

C2orf11; chromosome 2 open reading frame 11

+5.79

AK054688

PON2; paraoxonase 2

+6.99

Signal transducer activity

NM_005290

GPR15; G protein-coupled receptor 15

+7.47

AK026202

PTGDR; prostaglandin D2 receptor (DP)

+5.26

Unclassified

AL110152

CD109; CD109 antigen (Gov platelet alloantigens)

+6.20

NM_006408

AGR2; anterior gradient 2 homolog (Xenopus laevis)

-5.31

NM_004312

ARR3; arrestin 3, retinal (X-arrestin)

-8.08

NM_032149

C4orf17; chromosome 4 open reading frame 17

-6.81

AK024536

CADPS; Ca2+-dependent secretion activator

+8.45

BC015117

DEPDC4; DEP domain containing 4

+7.83

AK057372

FLJ32810; hypothetical protein FLJ32810

-14.32

AF305616

TMEPAI; transmembrane, prostate androgen induced RNA

+2.06

AK025272

Unkown

+15.27

AK021730

Unkown

+31.81

AF130053

Unkown

+23.33

AL080106

Unkown

+4.04

AK021569

Unkown

+16.22

AK001133

Unkown

+7.59

AK055083

Unkown

+6.91

  1. *Bold indicated genes investigated further by RT-PCR