Figure 1

Chemosensitivity towards doxorubicin of SCC cell lines. Percent cell viability following doxorubicin treatment to assess chemosensitivity towards doxorubicin was measured by MTT assays. SCC cell lines were grown under normoxic (▽ SCC-4, ■ SCC-10B and □ SCC-9) or hypoxic (● SCC-4, ○ SCC-10B, and ▼ SCC-9) conditions and treated with various concentrations of doxorubicin. Significant differences between cell lines grown under hypoxic conditions and normoxic conditions was detected for all three cell lines as determined by two-tailed Student's t test (p ≤ 0.05). The error bars represent the S.E.M. for 3 experiments.