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Table 1 List of p53 responsive genes (n = 37). 26 genes were up-regulated and 11 genes were down-regulated in the TGCT cells following cisplatin exposure

From: Molecular portrait of cisplatin induced response in human testis cancer cell lines based on gene expression profiles

UniGene ID

Gene Name

Description

SAM Score(d)

Referance (a)

p53 binding motifs (b)

A) 26 p53 target genes that are up-regulated in TGCT cells and down-regulated in HCT116 cells

Hs.306322

NAV3

Neuron navigator 3

7.60

2

+

Hs.553498

PIK3CA

Phosphoinositide-3-kinase, catalytic, alpha polypeptide

6.63

1

+

Hs.196054

HDAC9

Histone deacetylase 9

6.44

2

+

Hs.395482

PTK2

PTK2 protein tyrosine kinase 2

6.30

2

+

Hs.501778

TRIM22

Tripartite motif-containing 22

6.11

2,3&4

+

Hs.160871

PTPRO

Protein tyrosine phosphatase, receptor type, O

5.96

2

+

Hs.495473

NOTCH1

Notch homolog 1, translocation-associated (Drosophila)

5.73

2

+

Hs.591292

GPR87

G protein-coupled receptor 87

5.59

3

+

Hs.13291

CCNG2

Cyclin G2

5.27

2

+

Hs.65029

GAS1

Growth arrest-specific 1

5.13

1

+

Hs.592020

IGF1R

Insulin-like growth factor 1 receptor

5.09

1

+

Hs.591630

CASP8

Caspase 8, apoptosis-related cysteine peptidase

5.04

1

+

Hs.138211

MAPK8

Mitogen-activated protein kinase 8

5.03

1

+

Hs.89679

IL2

Interleukin 2

5.02

1

+

Hs.93842

STARD4

START domain containing 4, sterol regulated

4.95

2

+

Hs.326035

EGR1

Early growth response 1

4.90

1

+

Hs.40582

CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

4.52

1

+

Hs.634224

PIAS2

Protein inhibitor of activated STAT, 2

4.43

2

+

Hs.648190

ASTN2

Astrotactin 2 V-erb-a erythroblastic leukemia viral oncogene homolog 4

4.34

2

+

Hs.390729

ERBB4

(avian)

4.28

2

+

Hs.476018

CTNNB1

Catenin (cadherin-associated protein), beta 1, 88 kDa

4.22

1

+

Hs.591179

DGKE

Diacylglycerol kinase, epsilon 64 kDa

4.21

1

+

Hs.35947

MBD4

Methyl-CpG binding domain protein 4 SWI/SNF related, matrix associated, actin dependent

4.05

1

+

Hs.534350

SMARCB1

regulator of chromatin, subfamily b, member 1

4.03

2

+

Hs.545196

GML

GPI anchored molecule like protein

3.41

1&2

+

Hs.208124

ESR1*

Estrogen receptor 1

3.04

1

+

B) 11 p53 target genes that are down-regulated in TGCT cells and up-regulated in HCT116 cells

Hs.388613

NEO1*

Neogenin homolog 1 (chicken)

-7.00

2

+

Hs.124922

LRMP

Lymphoid-restricted membrane protein

-5.99

4

+

Hs.168132

IL15

Interleukin 15

-5.77

1

+

Hs.256126

BIRC7

Baculoviral IAP repeat-containing 7 (livin)

-5.59

1

+

Hs.76171

CEBPA

CCAAT/enhancer binding protein (C/EBP), alpha

-5.45

1

+

Hs.78960

LATS2*

LATS, large tumor suppressor, homolog 2 (Drosophila)

-4.54

2

+

Hs.271955

TNFAIP8

Tumor necrosis factor, alpha-induced protein 8

-4.46

2

+

Hs.397465

HIPK2

Homeodomain interacting protein kinase 2

-4.37

1

+

Hs.291363

CHEK2

CHK2 checkpoint homolog (S. pombe)

-4.26

1

+

Hs.508423

ABCC4

ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Solute carrier family 7 (cationic amino acid transporter, y+

-4.06

1

+

Hs.334848

SLC7A6

system), member 6

-3.95

4

+

  1. a) Predicted and known p53 target genes based on following references (1) Zhao et al. (2005) [38], (2) Wei et al. (2006) [80], (3) Kerley-Hamilton et al. (2005) [35]and (4) Barenco et al. (2006) [81]). b) These genes have a consensus p53-responsive element (MA0106) upstream of their predicted transcriptional start site according to the JASPAR database [39,40].* NEO1, LATS2 and ESR1 are the only target genes common for both p53 and hsa- mir-372 and 373.
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Molecular Cancer

ISSN: 1476-4598