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Table 1 List of p53 responsive genes (n = 37). 26 genes were up-regulated and 11 genes were down-regulated in the TGCT cells following cisplatin exposure

From: Molecular portrait of cisplatin induced response in human testis cancer cell lines based on gene expression profiles

UniGene ID Gene Name Description SAM Score(d) Referance (a) p53 binding motifs (b)
A) 26 p53 target genes that are up-regulated in TGCT cells and down-regulated in HCT116 cells
Hs.306322 NAV3 Neuron navigator 3 7.60 2 +
Hs.553498 PIK3CA Phosphoinositide-3-kinase, catalytic, alpha polypeptide 6.63 1 +
Hs.196054 HDAC9 Histone deacetylase 9 6.44 2 +
Hs.395482 PTK2 PTK2 protein tyrosine kinase 2 6.30 2 +
Hs.501778 TRIM22 Tripartite motif-containing 22 6.11 2,3&4 +
Hs.160871 PTPRO Protein tyrosine phosphatase, receptor type, O 5.96 2 +
Hs.495473 NOTCH1 Notch homolog 1, translocation-associated (Drosophila) 5.73 2 +
Hs.591292 GPR87 G protein-coupled receptor 87 5.59 3 +
Hs.13291 CCNG2 Cyclin G2 5.27 2 +
Hs.65029 GAS1 Growth arrest-specific 1 5.13 1 +
Hs.592020 IGF1R Insulin-like growth factor 1 receptor 5.09 1 +
Hs.591630 CASP8 Caspase 8, apoptosis-related cysteine peptidase 5.04 1 +
Hs.138211 MAPK8 Mitogen-activated protein kinase 8 5.03 1 +
Hs.89679 IL2 Interleukin 2 5.02 1 +
Hs.93842 STARD4 START domain containing 4, sterol regulated 4.95 2 +
Hs.326035 EGR1 Early growth response 1 4.90 1 +
Hs.40582 CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 4.52 1 +
Hs.634224 PIAS2 Protein inhibitor of activated STAT, 2 4.43 2 +
Hs.648190 ASTN2 Astrotactin 2 V-erb-a erythroblastic leukemia viral oncogene homolog 4 4.34 2 +
Hs.390729 ERBB4 (avian) 4.28 2 +
Hs.476018 CTNNB1 Catenin (cadherin-associated protein), beta 1, 88 kDa 4.22 1 +
Hs.591179 DGKE Diacylglycerol kinase, epsilon 64 kDa 4.21 1 +
Hs.35947 MBD4 Methyl-CpG binding domain protein 4 SWI/SNF related, matrix associated, actin dependent 4.05 1 +
Hs.534350 SMARCB1 regulator of chromatin, subfamily b, member 1 4.03 2 +
Hs.545196 GML GPI anchored molecule like protein 3.41 1&2 +
Hs.208124 ESR1* Estrogen receptor 1 3.04 1 +
B) 11 p53 target genes that are down-regulated in TGCT cells and up-regulated in HCT116 cells
Hs.388613 NEO1* Neogenin homolog 1 (chicken) -7.00 2 +
Hs.124922 LRMP Lymphoid-restricted membrane protein -5.99 4 +
Hs.168132 IL15 Interleukin 15 -5.77 1 +
Hs.256126 BIRC7 Baculoviral IAP repeat-containing 7 (livin) -5.59 1 +
Hs.76171 CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -5.45 1 +
Hs.78960 LATS2* LATS, large tumor suppressor, homolog 2 (Drosophila) -4.54 2 +
Hs.271955 TNFAIP8 Tumor necrosis factor, alpha-induced protein 8 -4.46 2 +
Hs.397465 HIPK2 Homeodomain interacting protein kinase 2 -4.37 1 +
Hs.291363 CHEK2 CHK2 checkpoint homolog (S. pombe) -4.26 1 +
Hs.508423 ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Solute carrier family 7 (cationic amino acid transporter, y+ -4.06 1 +
Hs.334848 SLC7A6 system), member 6 -3.95 4 +
  1. a) Predicted and known p53 target genes based on following references (1) Zhao et al. (2005) [38], (2) Wei et al. (2006) [80], (3) Kerley-Hamilton et al. (2005) [35]and (4) Barenco et al. (2006) [81]). b) These genes have a consensus p53-responsive element (MA0106) upstream of their predicted transcriptional start site according to the JASPAR database [39,40].* NEO1, LATS2 and ESR1 are the only target genes common for both p53 and hsa- mir-372 and 373.