Table 4 Terminal differentiation or senescence related genes (n = 29) induced in TGCT cells following cisplatin exposure
UniGene ID | Gene Name | Description | SAM Score(d) |
|---|---|---|---|
A) 5 genes from Schwarze et al (2002) | |||
Hs.1722 | IL1A | Interleukin 1, alpha | 8.62 |
Hs.138211 | MAPK8 | Mitogen-activated protein kinase 8 | 5.03 |
Hs.484551 | CPM | Carboxypeptidase M | 4.88 |
Hs.504877 | ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 4.57 |
Hs.89649 | EPHX1 | Epoxide hydrolase 1, microsomal (xenobiotic) | 4.52 |
B) 3 genes from Chang et al (2001) | |||
Hs.135646 | ELF1 | E74-like factor 1 (ets domain transcription factor) | 5.47 |
Hs.134221 | MBNL2 | Muscleblind-like 2 (Drosophila) | 4.92 |
Hs.224012 | JAG1 | Jagged 1 (Alagille syndrome) | 4.00 |
C) 6 Testis-specific genes | |||
Hs.98367 | SOX17 | SRY (sex determining region Y)-box 17 | 6.36 |
Hs.351068 | SPATA22 | Spermatogenesis associated 22 | 6.23 |
Hs.528821 | SPAG17 | Sperm associated antigen 17 | 5.29 |
Hs.121494 | SPAM1 | Sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) | 4.94 |
Hs.213194 | SOX7 | SRY (sex determining region Y)-box 7 | 4.84 |
Hs.629177 | TCAM1 | Testicular cell adhesion molecule 1 homolog (mouse) | 4.67 |
D) 2 Germ cell development related genes | |||
Hs.632137 | CUGBP1 | CUG triplet repeat, RNA binding protein 1 | 4.78 |
Hs.436445 | OSGIN2 | Oxidative stress induced growth inhibitor family member 2 | 4.59 |
E) Other differentiation or senescence related genes (n = 13) | |||
Hs.119693 | PCDHB5 | Protocadherin beta 5 | 7.92 |
Hs.489142 | COL1A2 | Collagen, type I, alpha 2 | 6.48 |
Hs.372946 | LOC440895 | Similar to LIM and senescent cell antigen-like domains 3 | 5.98 |
Hs.55999 | NKX3-1 | NK3 transcription factor related, locus 1 (Drosophila) | 5.52 |
Hs.54473 | NKX2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 5.08 |
Hs.154210 | EDG1 | Endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 | 4.99 |
Hs.645216 | IGFBP7 | Insulin-like growth factor binding protein 7 | 4.99 |
Hs.522805 | CD99L2 | CD99 molecule-like 2 | 4.45 |
Hs.234763 | NKX2-8 | NK2 transcription factor related, locus 8 (Drosophila) | 4.45 |
Hs.274313 | IGFBP6 | Insulin-like growth factor binding protein 6 | 4.14 |
Hs.528847 | MYADML | Myeloid-associated differentiation marker-like | 3.99 |
Hs.555902 | DDEF2 | Development and differentiation enhancing factor 2 | 3.88 |
Hs.106015 | DDEF1 | Development and differentiation enhancing factor 1 | 3.87 |