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Table 4 Terminal differentiation or senescence related genes (n = 29) induced in TGCT cells following cisplatin exposure

From: Molecular portrait of cisplatin induced response in human testis cancer cell lines based on gene expression profiles

UniGene ID Gene Name Description SAM Score(d)
A) 5 genes from Schwarze et al (2002)
Hs.1722 IL1A Interleukin 1, alpha 8.62
Hs.138211 MAPK8 Mitogen-activated protein kinase 8 5.03
Hs.484551 CPM Carboxypeptidase M 4.88
Hs.504877 ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 4.57
Hs.89649 EPHX1 Epoxide hydrolase 1, microsomal (xenobiotic) 4.52
B) 3 genes from Chang et al (2001)
Hs.135646 ELF1 E74-like factor 1 (ets domain transcription factor) 5.47
Hs.134221 MBNL2 Muscleblind-like 2 (Drosophila) 4.92
Hs.224012 JAG1 Jagged 1 (Alagille syndrome) 4.00
C) 6 Testis-specific genes
Hs.98367 SOX17 SRY (sex determining region Y)-box 17 6.36
Hs.351068 SPATA22 Spermatogenesis associated 22 6.23
Hs.528821 SPAG17 Sperm associated antigen 17 5.29
Hs.121494 SPAM1 Sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 4.94
Hs.213194 SOX7 SRY (sex determining region Y)-box 7 4.84
Hs.629177 TCAM1 Testicular cell adhesion molecule 1 homolog (mouse) 4.67
D) 2 Germ cell development related genes
Hs.632137 CUGBP1 CUG triplet repeat, RNA binding protein 1 4.78
Hs.436445 OSGIN2 Oxidative stress induced growth inhibitor family member 2 4.59
E) Other differentiation or senescence related genes (n = 13)
Hs.119693 PCDHB5 Protocadherin beta 5 7.92
Hs.489142 COL1A2 Collagen, type I, alpha 2 6.48
Hs.372946 LOC440895 Similar to LIM and senescent cell antigen-like domains 3 5.98
Hs.55999 NKX3-1 NK3 transcription factor related, locus 1 (Drosophila) 5.52
Hs.54473 NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 5.08
Hs.154210 EDG1 Endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 4.99
Hs.645216 IGFBP7 Insulin-like growth factor binding protein 7 4.99
Hs.522805 CD99L2 CD99 molecule-like 2 4.45
Hs.234763 NKX2-8 NK2 transcription factor related, locus 8 (Drosophila) 4.45
Hs.274313 IGFBP6 Insulin-like growth factor binding protein 6 4.14
Hs.528847 MYADML Myeloid-associated differentiation marker-like 3.99
Hs.555902 DDEF2 Development and differentiation enhancing factor 2 3.88
Hs.106015 DDEF1 Development and differentiation enhancing factor 1 3.87