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Figure 2 | Molecular Cancer

Figure 2

From: Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells

Figure 2

Microarray design. (A) Cells cultured in normal sera media were transfected with 90 nM control siRNAs (scrambled or RISC-free) or three separate RIP140 siRNAs. Cells were than split into DMSO, vehicle treatment or 10 μM RA treatment for 24 hours prior to harvesting for mRNA. (B) Possible outcomes of RIP140 siRNA on RA-dependent and RA-independent gene expression. -, no change or no expression; ++ or ++++, expression or increased expression. (C) Northern analysis of actual samples for microarray analysis depicting repression of RIP140 expression with indicated RIP140 siRNA and associated enhancement of RARβ expression. Included are mock transfected cells (no siRNA).

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Molecular Cancer

ISSN: 1476-4598