Molecular signatures define two main classes of meningiomas

Table 3 Pathways significantly altered between grade 1 and grade 3 meningiomas by GenMAPP analysis of genes altered^a

Database	Mapp or GO name	P value	Number Changed^b	Percent Changed^c
Local Mapp	Hs 2 Tissues Endocrine and CNS	0.000	25	24.3
	M phase of mitotic cell cycle	0.001	26	21.7
	extracellular matrix (sensu Metazoa)	0.008	32	18.6
	Hs TGF Beta Signaling Pathway	0.008	14	26.9
	M phase	0.010	29	18.8
	Hs Focal adhesion KEGG	0.012	33	17.6
	Hs 1 Tissue Embryonic Stem Cell	0.044	12	25.5
Gene Ontology	spindle organization and biogenesis	0.000	11	57.9
	extracellular matrix	0.000	50	19.6
	extracellular matrix (sensu Metazoa)	0.001	49	19.7
	cell division	0.017	33	22.1
	extracellular region	0.023	117	12.1
	spindle	0.024	11	39.3
	cell adhesion	0.025	73	13.7
	mitotic cell cycle	0.026	33	19.2
	mitosis	0.049	26	21.1

^aThe results were obtained using a criterion of p ≤ 0.05 and fold-difference ≥ 2. ^bThe number of genes mapping to a particular pathway that are altered is listed. ^cThe percentage of total genes belonging to a particular pathway that are altered is listed.

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