Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized

Table 2 Genes and Promoter Elements That Define Post-Selection HMEC Gene Expression Classes

Geneset Classes	Genes	Promoter Elements
Group A
IFN genes	IFIT1, BST2, G1P2, G1P3, IFIT2, OAS1, IFI44, IFIT4	IRF, ILR, IRL
Non-IFN genes	CTAG2, ARHGDI-B/Ly-GDI, MMP7, PLAU, CALB1, SLC1A6, MDA5, FXYD5, HMOX1
Group B	NUCKS, HDAC3, TRAP150, HOXB2, SON, IF2, LZ16, ANLN, BBX, TOP1, H4FG, SFRP1, KTN1, GTAR, BAZ1A, PK428, FALZ, TTC3, DNCL12, RBM9	SP1
Group C	TOP2A, RRM2, KIF20A, BIRC5, ANKT, CCNA2, CDC2, MKI67, CDC20, MCM5, HMMR, IL-1B, PRC1, PMSCL1, MADL1, DLG7	E2F, NF-Y, B-Myb
Group D	H11, COL11A1, IGFBP5, CNN1, COMP, LGALS7, CLDN7, KLK6, KLK7, KLK10, KLK11 KRT23, LOXL4, THY1, FLJ21841	MAZ, MAZR, MEF-3

ISSN: 1476-4598