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Table 3 Performance of top four markers in samples based on gender, race/ethnicity and stage

From: Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma

  Median PMR, Tumor Tumor Median PMR, AdjNTL p-valuea
GENDER    
Male n = 28 n = 19  
CDKN2A EX2 199.44 51.88 5.0E-06
CDX2 28.40 4.78 2.0E-05
HOXA1 139.51 5.06 4.6E-05
OPCML 76.62 11.27 1.6E-06
Female n = 14 n = 10  
CDKN2A EX2 189.16 38.64 1.3E-04
CDX2 114.71 3.15 4.0E-06
HOXA1 188.13 1.34 3.1E-06
OPCML 154.32 5.36 3.1E-06
RACE    
White Hispanic n = 14 n = 10  
CDKN2A EX2 165.47 37.52 6.0E-04
CDX2 39.49 1.98 2.0E-04
HOXA1 52.98 1.75 7.7E-03
OPCML 142.56 8.17 6.0E-04
White Non-Hispanic n = 14 n = 10  
CDKN2A EX2 314.35 38.00 5.0E-04
CDX2 110.73 4.78 0.001
HOXA1 231.66 4.90 4.6E-05
OPCML 179.79 6.54 4.7E-05
Black n = 11 n = 7  
CDKN2A EX2 194.91 51.88 0.015
CDX2 129.96 9.11 0.024
HOXA1 128.52 6.16 0.011
OPCML 91.15 14.29 0.005
Asian n = 6 n = 4  
CDKN2A EX2 145.56 39.81 0.11
CDX2 24.28 1.78 0.023
HOXA1 117.49 0.99 0.014
OPCML 88.81 4.67 0.014
STAGE b    
Stage IA n = 12 n = 12  
CDKN2A EX2 182.57 47.28 4.9E-04
CDX2 99.71 3.15 4.9E-04
HOXA1 143.06 3.25 0.001
OPCML 189.43 7.65 4.9E-04
Stage IB n = 6 n = 6  
CDKN2A EX2 190.67 61.00 0.031
CDX2 20.62 13.36 0.31
HOXA1 78.98 2.15 0.063
OPCML 76.62 15.16 0.063
Stage IIA/IIB/IIIA c n = 10 n = 10  
CDKN2A EX2 208.05 39.81 0.01
CDX2 83.22 1.78 0.002
HOXA1 180.18 6.16 0.002
OPCML 178.54 8.25 0.002
  1. ap-value calculated by Mann-Whitney for gender and race and Wilcoxon signed rank test for stage, in which paired adjacent samples were used. Italics: p > 0.05; b Paired adjacent samples; c Only one paired sample was available for stages IIA and IIIA and none for IIIB, hence IIA/IIB/IIIA were pooled.