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Table 3 Performance of top four markers in samples based on gender, race/ethnicity and stage

From: Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma

 

Median PMR, Tumor Tumor

Median PMR, AdjNTL

p-valuea

GENDER

   

Male

n = 28

n = 19

 

CDKN2A EX2

199.44

51.88

5.0E-06

CDX2

28.40

4.78

2.0E-05

HOXA1

139.51

5.06

4.6E-05

OPCML

76.62

11.27

1.6E-06

Female

n = 14

n = 10

 

CDKN2A EX2

189.16

38.64

1.3E-04

CDX2

114.71

3.15

4.0E-06

HOXA1

188.13

1.34

3.1E-06

OPCML

154.32

5.36

3.1E-06

RACE

   

White Hispanic

n = 14

n = 10

 

CDKN2A EX2

165.47

37.52

6.0E-04

CDX2

39.49

1.98

2.0E-04

HOXA1

52.98

1.75

7.7E-03

OPCML

142.56

8.17

6.0E-04

White Non-Hispanic

n = 14

n = 10

 

CDKN2A EX2

314.35

38.00

5.0E-04

CDX2

110.73

4.78

0.001

HOXA1

231.66

4.90

4.6E-05

OPCML

179.79

6.54

4.7E-05

Black

n = 11

n = 7

 

CDKN2A EX2

194.91

51.88

0.015

CDX2

129.96

9.11

0.024

HOXA1

128.52

6.16

0.011

OPCML

91.15

14.29

0.005

Asian

n = 6

n = 4

 

CDKN2A EX2

145.56

39.81

0.11

CDX2

24.28

1.78

0.023

HOXA1

117.49

0.99

0.014

OPCML

88.81

4.67

0.014

STAGE b

   

Stage IA

n = 12

n = 12

 

CDKN2A EX2

182.57

47.28

4.9E-04

CDX2

99.71

3.15

4.9E-04

HOXA1

143.06

3.25

0.001

OPCML

189.43

7.65

4.9E-04

Stage IB

n = 6

n = 6

 

CDKN2A EX2

190.67

61.00

0.031

CDX2

20.62

13.36

0.31

HOXA1

78.98

2.15

0.063

OPCML

76.62

15.16

0.063

Stage IIA/IIB/IIIA c

n = 10

n = 10

 

CDKN2A EX2

208.05

39.81

0.01

CDX2

83.22

1.78

0.002

HOXA1

180.18

6.16

0.002

OPCML

178.54

8.25

0.002

  1. ap-value calculated by Mann-Whitney for gender and race and Wilcoxon signed rank test for stage, in which paired adjacent samples were used. Italics: p > 0.05; b Paired adjacent samples; c Only one paired sample was available for stages IIA and IIIA and none for IIIB, hence IIA/IIB/IIIA were pooled.
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Molecular Cancer

ISSN: 1476-4598