Figure 6
From: DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines
Basal-like breast cancers express a hypermethylator signature. Gene expression data from 92 primary human breast tumors from the UNC Microarray Database were subjected to unsupervised cluster analysis based upon the mRNA expression of six genes (CEACAM6, CDH1, CST6, ESR1, LCN2, and SCNN1A) which define the hypermethylator phenotype. Four tumors failed to cluster and were excluded from further analysis. Gene designations are depicted vertically and tumor designations are shown horizontally. Four clusters (designated A-D) were identified: Cluster A (majority of which are luminal), Cluster B (majority Her2+), Cluster C (majority luminal), and Cluster D (all basal-like). The expression level for each gene is shown relative to the median expression of that gene across all samples, with high expression shown in red and low expression shown in green, while genes with median expression are shown in black. Tumors were classified as luminal A or luminal B (shown in blue), Her2+ (shown in purple), basal-like (shown in red), or normal-like (shown in green).