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Figure 6 | Molecular Cancer

Figure 6

From: Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cγ at the centrosome

Figure 6

Schematic representation of the centrosome depicting FOP-FGFR1 and its partners. FOP-FGFR1 interacts with the centrosomal protein CAP350 through the FOP moiety. From this platform, the centrosomal FOP-FGFR1 protein recruits PI3K in particular through interaction with Y475 of FOP-FGFR1, and recruits PLCγ1 through interaction with Y511. The PI3K and PLCγ1 pathways are activated and are important to induce the effects of FOP-FGFR1 at the centrosome.

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Molecular Cancer

ISSN: 1476-4598