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Figure 1 | Molecular Cancer

Figure 1

From: Altered splicing of CEACAM1 in breast cancer: Identification of regulatory sequences that control splicing of CEACAM1 into long or short cytoplasmic domain isoforms

Figure 1

Schematic representation of human CEACAM1 gene and its alternative splicing into long and short cytoplasmic domain isoforms. Open boxes or lines represent exons and introns, respectively. Shaded portions of exons denote the leader sequence. The broken lines represent inclusion or exclusion of exon 7 thereby generating CEACAM1-L or CEACAM1-S splice variants, respectively. Numbering of the exons is indicated below each exon. N, A1, B1 and A2 refer to the Ig domains [54]. UTR, untranslated region; ATG, the start codon; TM, transmembrane domain; CP, cytoplasmic domain; TGA and TAA, the stop codons for short and long cytoplasmic domain isoform, respectively.

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Molecular Cancer

ISSN: 1476-4598