Figure 2From: Effect of bortezomib on human neuroblastoma: analysis of molecular mechanisms involved in cytotoxicityBortezomib induces apoptosis in neuroblastoma cells. Sensitive (IMR32 and SKNAS) and resistant (CLB-sedp) neuroblastoma cell lines were treated with or without 10 nM bortezomib for 72 h. Cells were stained with HOECHST 33258 (2 μl/ml). Apoptotic cells were identified by condensation and fragmentation of nuclei using a Zeiss Axiovert inverted light microscope.Back to article page