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Table 1 The sensitivity of NB cell lines to NaB, SAHA and TSA is independent of MYCN and p53 status.

From: Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells

cell line IC50 NaB (mM) IC50 SAHA (uM) IC50 TSA (uM) MYCN status p53
SH-EP 11.1 ± 2.5 6.3 ± 3.0 1.3 ± 0.9 s.c. wt
CA2E 5.9 ± 1.5 4.5 ± 3.0 0.4 ± 0.1 A N.D.
SK-N-AS 13 ± 2.9 2.3 ± 0.3 0.3 ± 0.2 s.c. mt[45],[46]
LAN-1 3.3 ± 1.1 1.4 ± 0.3 0.3 ± 0.2 A mt[47]
IMR32 4.0 ± 1.4 2.5 ± 1.8 0.3 ± 0.2 A wt[47]
SH-SY-5Y 5.0 ± 2.8 1.6 ± 0.6 0.4 ± 0.1 s.c. wt
IGRN-91 3.8 ± 1.0 1.6 ± 0.4 0.7 ± 0.45 A mt[48]
IGRN-B8 14.4 ± 2.2 3.9 ± 0.2 0.5 ± 0.1 A mt[46]
  1. s.c., single copy; A, amplified; wt, wild type; mt, mutated; N.D., not described