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Table 1 The sensitivity of NB cell lines to NaB, SAHA and TSA is independent of MYCN and p53 status.

From: Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells

cell line

IC50 NaB (mM)

IC50 SAHA (uM)

IC50 TSA (uM)

MYCN status

p53

SH-EP

11.1 ± 2.5

6.3 ± 3.0

1.3 ± 0.9

s.c.

wt

CA2E

5.9 ± 1.5

4.5 ± 3.0

0.4 ± 0.1

A

N.D.

SK-N-AS

13 ± 2.9

2.3 ± 0.3

0.3 ± 0.2

s.c.

mt[45],[46]

LAN-1

3.3 ± 1.1

1.4 ± 0.3

0.3 ± 0.2

A

mt[47]

IMR32

4.0 ± 1.4

2.5 ± 1.8

0.3 ± 0.2

A

wt[47]

SH-SY-5Y

5.0 ± 2.8

1.6 ± 0.6

0.4 ± 0.1

s.c.

wt

IGRN-91

3.8 ± 1.0

1.6 ± 0.4

0.7 ± 0.45

A

mt[48]

IGRN-B8

14.4 ± 2.2

3.9 ± 0.2

0.5 ± 0.1

A

mt[46]

  1. s.c., single copy; A, amplified; wt, wild type; mt, mutated; N.D., not described