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Table 2 Genes down-regulated following CPT treatment in both U87-MG and DBTRG-05

From: Gene expression time-series analysis of Camptothecin effects in U87-MG and DBTRG-05 glioblastoma cell lines

GeneName Description
  DNA metabolism and replication
ADK Adenosine kinase
CDC45L Cell division cycle 45 like
DTYMK Deoxythymidylate kinase (dTMP kinase)
FEN1 Flap structure specific endonuclease 1
H2AFZ H2A histone family Z
KIAA0101 The PCNA-associated factor KIAA0101/p15(PAF)
MCM2 Mini chromosome maintenance deficient 2
MCM3 Minichromosome maintenance deficient 3
MCM7 Minichromosome maintenance deficient 7
RRM1 Ribonucleotide reductase M1 subunit,
RRM2 Ribonucleotide reductase subunit M2,
TYMS Thymidylate synthetase
UHRF1 Nuclear protein 95
  Cell cycle and mitosis
ANKT nucleolar and spindle associated protein 1
BIRC5 Survivin
CCNA2 Cyclin A2
CDC2 Cell division cycle 2
CDCA5 cell division cycle associated 5
KNSL6 Mitotic centromere-associated kinesin (kinesin-like 6)
PRC1 Protein regulator of cytokinesis 1
STMN1 Stathmin 1 (oncoprotein 18)
TOPK PDZ-binding kinase
UBE2C Ubiquitin-conjugating enzyme E2C
ZWINT ZW10 interactor
DKFZp762E1312 Protein of unknown function
I_932099 Protein with high similarity to human HNRPA1,
ID1 Inhibitor of DNA binding 1
KPNA2 Karyopherin alpha 2 (importin alpha 1),
LOXL2 Lysyl oxidase-like 2
p100 EBNA-2 co-activator (100 kD)
SPOCK Testican
TSSC3 Tumor suppressing subtransferable candidate 3
UBE2T ubiquitin-conjugating enzyme E2T