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Table 4 Multivariate analysis for the risk factors associated with MSI-H occurrence (Model including single term and interactions effect)

From: Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study

Factor

OR (95% CI)

P value

Normal hMLH1 expression by IHC

0.13(0.04–0.41)

< 0.0001

BRAF V600E mutation

12.11(2.82–52.03)

0.001

hMLH1 methylation

13.84(1.05–182.72)

0.046

Race

 

0.946

   African-Americans

1

 

   Omani

0.83(0.04–0.18.30)

0.905

   Iranian

0.68(0.07–6.58)

0.739

hMLH1 methylation* Race

 

0.072

hMLH1 methylation* Omani

0.04(0.01–1.74)

0.091

hMLH1 methylation* Iranian

0.02(0.01–0.63)

0.032

  1. * indicates the interaction term between two variables.
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Molecular Cancer

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