Table 5 Genes that were highly affected by the knock-down of ALDH1A1 and ALDH3A1 in A549 lung cancer cell line.

CCL20 (MIP-3α)

NM_004591

2q33-q37

- 9.5

Chemokine ligand 20 is a ligand for CCR6. Upregulated in hepatocellular carcinoma. Part of the immune and inflammatory response in the lungs. Lack of expression of CCR6 on Lewis lung cancer decreases metastasis. Important for invasiveness of pancreatic and colon cancers. Expressed in oral SCCA.

GPR37

U87460

7q31

- 13.5

Highly expressed in brain neurons. If parkin absent, it accumulates and causes cell death & degeneration (Parkinson's disease). The neuropeptide head activator (HA) is a high-affinity ligand for GPR37. Hypermethylated frequently in AML.

DDX3Y

NM_004660

Yq11

- 7.45

Belongs to the DEAD-box RNA helicase family. Alter RNA secondary structure. Role in RNA splicing and transport. A candidate for tumor suppressor gene.

ID4

AW157094

6p22-p21

-16.12

Transcription factor. It inhibits binding to DNA and transcriptional transactivation by heterodimerization with bHLH protein. Expressed in small cell lung cancer. It is deregulated in ALL with t(6;14), gastric adenoca, and bladder cancer. Part of TGF-β pathway. Possible tumor suppressor gene

HMGA2

NM_003483

12q15

- 6.6

Belongs to non-histone chromosomal high mobility group protein family. It affects chromatin structure & DNA binding. Involved in obesity, pituitary adenomas, lipomas, serous cancer of overy, MDS, malignant transformation of oral cancer. Overexpressed in NSCLC, thyroid cancer, CML, prostate and possibly others. Detection of its mRNA in blood, prognostic for breast cancer patients.

GPC6

AI651255

13q32

- 7.5

A cell surface proteoglycan. Involved in cell growth and division. Co-receptor for growth factors

RPS4Y1

NM_001008

Yp11.3

- 9.06

Ribosomal protein 4 belongs to the S4E family. Involved in translation

EIF1AY

NM_004681

Yq11.222

-18

Eukaryotic initiation factor 1A, required for the binding of 43S (a 40S subunit) to the 5' end of capped RNA.