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Figure 1 | Molecular Cancer

Figure 1

From: Geographical mapping of a multifocal thyroid tumour using genetic alteration analysis & miRNA profiling

Figure 1

TaqMan® SNP assays for BRAF V600E mutation detection. DNA from the TPC1, BC-PAP, and K-2 cell lines was used for positive control purposes. TPC1 contains the wild type BRAF allele, K-2 is heterozygous for the mutant allele, and BC-PAP is homozygous for the mutant allele. The figure shows clustering of the samples into 3 distinct groups depending on their respective levels of VIC/FAM fluorescence: homozygous T1799A mutation (●), homozygous wild-type/normal (●) and heterozygous T1799 mutation (●). Negative controls and undetermined samples are also displayed (×). The two classic PTC tumour areas are the only ones that exhibit the BRAF mutation.

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Molecular Cancer

ISSN: 1476-4598