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Figure 1 | Molecular Cancer

Figure 1

From: Intravenous administration of the conditionally replicative adenovirus Ad5-Δ24RGD induces regression of osteosarcoma lung metastases

Figure 1

Therapeutic effect of Ad5-Δ24RGD infusion 1–3 (left panel figure a & b) or 5–7 (right panel figure a & b) weeks after SaOs-lm7 injection. (a) Effect of intravenous administration of Ad5-Δ24RGD on OS pulmonary tumor burden. Lungs were removed and weighed. Open circles depict lung weight of each mouse and black lines show the median of each group. (b) Macroscopic appearance of dissected lungs. (c) Number of lung tumor nodules per mouse. (d) Immunohistochemical staining for expression of the adenovirus hexon protein in lungs of mice treated at weeks 5–7. Ten weeks after tumor cell injection and three weeks after the last virus injection lungs were isolated and analyzed for hexon expression. Representative pictures of the lungs from a PBS control mouse and two Ad5-Δ24RGD treated mice (A & B) are shown at 10× and 40× magnification.

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Molecular Cancer

ISSN: 1476-4598