Figure 2
From: Gene expression deregulation by KRAS G12D and G12V in a BRAF V600E context
Microarray analysis performed with TIGR MeV program: principal component analysis. Microarray analysis of Colo741 cell clones transfected with constructs expressing the KRASG 12D(G12D), KRASG 12V(G12V) and KRASWT(WT) isoforms. Probe sets associated to dysregulation of gene expression levels among the three groups were identified using SAM (see Materials and Methods). The corresponding values from two independent microarray analysis were averaged. Principal component analysis (PCA) is shown to provide the 2D projections onto the plane spanned by the two principal components for the three different KRAS profiling data sets.